Pavlina Rezacova

Position:	Postdoctoral Researcher
Address:	5323 Harry Hines Blvd.   Dallas, Texas 75390-9038
Office:	ND10.214D
Phone:	214-648-3801
Fax:	214-648-8954
Email:

Education:

• Ph.D.- Molecular biology, Genetics and Virology - Charles University, Prague, Czech Republic, 2004
• M.Sc. - Molecular biology, Genetics and Virology - Charles University, Prague, Czech Republic, 1997
• Bc. - Biology - Charles University, Prague, Czech Republic, 1995

Research Interests:

• Biochemical and structural studies of HIV protease
• Biochemical and structural studies of antibodies
• Stucture-based inhibitor design

Publications:

Rezacova P., Brynda J., Lescar J., Fabry M., Horejsi M., Sieglova I., Sedlacek J., Bentley G.A.: Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide. J. Struct. Biol. (2005) 149: 332-337

Brynda J., Rezacova P., Fabry M., Horejsi M., Stouracova R., Soucek M., Hradilek M., Konvalinka J., Sedlacek J.: Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex. Acta Cryst. (2004) D60:1943-1948

Brynda J., Rezacova P., Fabry M., Horejsi M., Stouracova R., Sedlacek J., Soucek M., Hradilek M., Lepsik M., Konvalinka J.: A Phenylnorstatine Inhibitor Binding to HIV-1 Protease: Geometry, Protonation, and Subsite-Pocket Interactions Analyzed at Atomic Resolution. J. Med. Chem. (2004) 47: 2030-2036

Lescar J., Brynda J., Fabry M. Horejsi M.,Rezacova P., Sedlacek J., Bentley G. A.: Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases. Acta Cryst. (2003) D59: 955-957

Rezacova P., Brynda J., Fabry M., Horejsi M., Stouracova R., Lescar J., Chitarra V., Riottot M-M., Sedlacek J., Bentley G. A.: Inhibition of HIV protease by monoclonal antibodies. J. Mol. Recognit. (2002) 15: 272-276

Rezacova P., Lescar J., Brynda J., Fabry M., Horejsi M., Sedlacek J., Bentley G.A.: Structural basis of HIV-1 and HIV-2 protease inhibition by a monoclonal antibody.  Structure (2001) 9: 887-895

Kmoch S., Brynda J., Asfaw B., Bezouska K., Novak P., Rezacova P., Ondrova L., Filipec M., Sedlacek J., Elleder M.: Link between a novel human gammaD-crystallin allele and a unique cataract phenotype explained by protein crystallography. Hum Mol Genet. (2000) 9:1779-86

Lescar J., Brynda J., Rezacova P., Stouracova R., Riottot M-M., Chitarra V., Fabry M., Horejsi M., Sedlacek J., Bentley G.A.: Inhibition of the HIV-1 and HIV-2 proteases by a monoclonal antibody. Protein Sci. (1999) 8: 2686-2696